Sfoglia per Autore "Maggiolini, Marcello"
Items 1-12 di 12
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Bisphenol A induces gene expression changes an proliferative effects through GPER in breast cancer celles and cancer-associated fibroblasts
Pupo, Marco; Maggiolini, Marcello; Sisci, Diego (2012)Bisphenol A (BPA) is the principal constituent of baby bottles, reusable water bottles, metal cans, and plastic food containers. BPA exerts estrogen-like activity by interacting with the classical estrogen receptors (ER ... -
Different medicinal chemistry approaches towards the identification of novel targets in breast cancer
Pisano, Assunta; Bartolino, Roberto; Gabriele, Bartolo; Sindona, Giovanni; Maggiolini, Marcello (2013-12-02)G protein-coupled receptors (GPCRs) belong to the largest family of cellsurface molecules representing the targets of approximately 40% of current medicinal drugs (Overington, J.P et al 2006). GPCRs are ubiquitous in ... -
Functional cooperation between GPER and AHR toward breast cancer progression
Cirillo, Francesca; Cerra, Maria Carmela; Maggiolini, Marcello (2019-04-11)The cytochrome P450 1B1 (CYP1B1) is a heme-thiolate monooxygenase involved in both estrogen and environmental contaminants metabolism. For instance, CYP1B1 catalyzes the hydroxylation of 17-β estradiol (E2) leading to ... -
GPER mediates the up-regulation of acid synthase (fasn) intuced by 17B-estradiol in cancer cell and in cancer-associated fibroblasts (CAFs)
Santolla, Maria Francesca; Maggiolini, Marcello; Sisci, Diego (2012-11-26)Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of many tumors. Fatty acid synthase (FASN) is a key lipogenic enzyme catalyzing the terminal steps in the de novo biogenesis of ... -
IGF system regulates GPER expression and function in cancer cells
De Marco, Paola; Maggiolini, Marcello; Sisci, Diego (2014-11-28) -
Molecular mechanisms determining aromatase overexpression and inducing rat tumor Leydig cell proliferation: involvement of IGF-I and COX-2
Chimento, Adele; Maggiolini, Marcello; De Benedictis, Giovanna (2007-10-26) -
Molecular mechanisms involved in the biological responses to estrogens and antiestrogens in cancer cell
Madeo, Antonio; Passarino, Giuseppe; Maggiolini, Marcello (2013-11-04) -
Novel molecular mechanisms involved in the stimulatory action of zinc in breast cancer
Perri, Maria Grazia; Sisci, Diego; Maggiolini, Marcello (2016-11-22)Lo Zinco (Zn), minerale essenziale che regola diverse funzioni biologiche, è coinvolto nella progressione del tumore mammario. In particolare, è stato dimostrato che in seguito all’attivazione indotta dallo Zn di recettori ... -
Ruolo di GPER sulla funzione cardiovascolare in condizioni di ipertensione: caratterizzazione fisiologica del recettore in Ratti Spontaneamente ipertesi (SHR)
De Francesco, Ernestina Marianna; Maggiolini, Marcello; Angelone, Tommaso (2013-11-25)Estrogens promote beneficial effects in the cardiovascular system mainly through the estrogen receptor (ER)α and ERβ, which act as ligand-gated transcription factors. Recently, the G protein-coupled estrogen receptor (GPER) ... -
Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
Avino, Silvia; Andò, Sebastiano; Maggiolini, Marcello (2017-06-12)Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved in the pathogenesis and development of various tumors. We have previously demonstrated that IGF-IR cooperates with the G-protein ... -
Targeting systems vulnerabilities in uveal melanoma by CRISPR Cas/9 focal adhesion kinase (FAK) genome editing and therapeutic inhibition
Rigiracciolo, Damiano Cosimo; Andò, Sebastiano; Maggiolini, Marcello (2018-02-27)Il Melanoma Uveale rappresenta la neoplasia intraoculare più frequente nell’età adulta. Colpisce circa 2,500 individui ogni anno negli USA ed il 50% dei pazienti affetti da tale neoplasia sviluppa metastasi entro 5 ... -
Torsin a acting as a mechanosensor modulates nuclear transport in pathophysiological conditions
Galli, Giulia Raffaella; Cerra, Maria Carmela; Maggiolini, Marcello (Università della Calabria, 2020-11-25)Gli esseri umani e l’ambiente circostante comunicano anche attraverso forze meccaniche. Gli input meccanici provenienti dal mondo che ci circonda svolgono un ruolo cruciale nei processi fisiologici e nel mantenimento ...