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Il Recettore Estrogenico alfa e IRS-1 (Insulin Receptor Substate-1) come target dell’azione del Recettore Estrogenico beta
(2013-10-21)
Estrogen signalling through ERα plays a central role in many diseases such as breast
and endometrial cancer, osteoporosis and cardiovascular disease. In 1996 it has been
discovered a second estrogen receptor in rat ...
Ruolo del sistema endocannabinoide nei meccanismi di neuroprotezione da 17β-estradiolo in un modello sperimentale di ischemia cerebrale focale
(2013-10-28)
In questo studio sono stati determinati i livelli endogeni dell’endocannabinoide finora
meglio caratterizzato, anandamide (AEA) e l’attività degli enzimi responsabili,
rispettivamente, della sua sintesi e degradazione, ...
<<The>> estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness
(2013-12-02)
The role of the Forkhead box class O (FoxO)3a transcription factor in breast
cancer migration and invasion is controversial. Here we show that FoxO3a
overexpression decreases motility, invasiveness, and anchorage-indep ...
Different medicinal chemistry approaches towards the identification of novel targets in breast cancer
(2013-12-02)
G protein-coupled receptors (GPCRs) belong to the largest family of cellsurface
molecules representing the targets of approximately 40% of
current medicinal drugs (Overington, J.P et al 2006). GPCRs are
ubiquitous in ...