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Advanced materials for pharmaceutical and biomedical purposes
(2018-02-27)
L'innovazione nella chimica dei materiali e nella nanotecnologia hanno
sinergicamente contribuito all'avanzamento e allo sviluppo dei Drug
Delivery Systems (DDS) creando devices in grado di proteggere farmaci e
sostanze ...
Estrogen receptor alpha interferes with LKBl/AMPK/mTOR signaling activation in adiponectin-treated breast cancer cells
(2018-02-27)
Breast cancer is the most common type of tumor and the leading cause of
cancer-related deaths in women, worldwide. The cause of breast cancer is
multifactorial and includes hormonal, genetic and environmental cues. Obesity ...
Role of ERalpha/NOTCH4 axis in sustaining stemness in breast cancer cells
(2018-02-27)
Early detection and new therapeutic strategies have improved breast cancer patient
outcome and survival rates in the last years. However, breast cancer still remains the
second leading cause of cancer-related deaths among ...
Advanced mass spectrometric approaches for the determination of food quality and development of new methodologies for enrichment of nutraceuticals in functional foods
(2018-02-27)
The research works presented in this Ph.D. thesis are based on the nutraceuticals and functional foods research.
The first part of the thesis deals with three main topics:
1. Structural characterization of new HMG-flavonoids ...
Targeting systems vulnerabilities in uveal melanoma by CRISPR Cas/9 focal adhesion kinase (FAK) genome editing and therapeutic inhibition
(2018-02-27)
Il Melanoma Uveale rappresenta la neoplasia intraoculare più frequente nell’età adulta. Colpisce circa 2,500
individui ogni anno negli USA ed il 50% dei pazienti affetti da tale neoplasia sviluppa metastasi entro 5 ...