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Identification and biochemical-molecular characterization of mitochondrial carrier proteins in human andmodel organisms and associated diseases
(2017-06-12)
The mitochondrial carriers (MCs) are transmembrane proteins found in the
mitochondrial inner membrane, which catalyze the translocation of solutes through the
membrane. These belong to a family of carrier proteins, the ...
Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy
(2017-06-12)
Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, ...
Role of ERalpha/NOTCH4 axis in sustaining stemness in breast cancer cells
(2018-02-27)
Early detection and new therapeutic strategies have improved breast cancer patient
outcome and survival rates in the last years. However, breast cancer still remains the
second leading cause of cancer-related deaths among ...
Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
(2017-06-12)
Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved
in the pathogenesis and development of various tumors. We have previously demonstrated
that IGF-IR cooperates with the G-protein ...
Advanced mass spectrometric approaches for the determination of food quality and development of new methodologies for enrichment of nutraceuticals in functional foods
(2018-02-27)
The research works presented in this Ph.D. thesis are based on the nutraceuticals and functional foods research.
The first part of the thesis deals with three main topics:
1. Structural characterization of new HMG-flavonoids ...
Targeting systems vulnerabilities in uveal melanoma by CRISPR Cas/9 focal adhesion kinase (FAK) genome editing and therapeutic inhibition
(2018-02-27)
Il Melanoma Uveale rappresenta la neoplasia intraoculare più frequente nell’età adulta. Colpisce circa 2,500
individui ogni anno negli USA ed il 50% dei pazienti affetti da tale neoplasia sviluppa metastasi entro 5 ...