Sfoglia Dipartimento di Farmacia e Scienze della Salute e della Nutrizione - Tesi di Dottorato per Autore "Maggiolini, Marcello"
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Bisphenol A induces gene expression changes an proliferative effects through GPER in breast cancer celles and cancer-associated fibroblasts
Pupo, Marco; Maggiolini, Marcello; Sisci, Diego (2012)Bisphenol A (BPA) is the principal constituent of baby bottles, reusable water bottles, metal cans, and plastic food containers. BPA exerts estrogen-like activity by interacting with the classical estrogen receptors (ER ... -
GPER mediates the up-regulation of acid synthase (fasn) intuced by 17B-estradiol in cancer cell and in cancer-associated fibroblasts (CAFs)
Santolla, Maria Francesca; Maggiolini, Marcello; Sisci, Diego (2012-11-26)Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of many tumors. Fatty acid synthase (FASN) is a key lipogenic enzyme catalyzing the terminal steps in the de novo biogenesis of ... -
IGF system regulates GPER expression and function in cancer cells
De Marco, Paola; Maggiolini, Marcello; Sisci, Diego (2014-11-28) -
Novel molecular mechanisms involved in the stimulatory action of zinc in breast cancer
Perri, Maria Grazia; Sisci, Diego; Maggiolini, Marcello (2016-11-22)Lo Zinco (Zn), minerale essenziale che regola diverse funzioni biologiche, è coinvolto nella progressione del tumore mammario. In particolare, è stato dimostrato che in seguito all’attivazione indotta dallo Zn di recettori ... -
Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
Avino, Silvia; Andò, Sebastiano; Maggiolini, Marcello (2017-06-12)Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved in the pathogenesis and development of various tumors. We have previously demonstrated that IGF-IR cooperates with the G-protein ... -
Targeting systems vulnerabilities in uveal melanoma by CRISPR Cas/9 focal adhesion kinase (FAK) genome editing and therapeutic inhibition
Rigiracciolo, Damiano Cosimo; Andò, Sebastiano; Maggiolini, Marcello (2018-02-27)Il Melanoma Uveale rappresenta la neoplasia intraoculare più frequente nell’età adulta. Colpisce circa 2,500 individui ogni anno negli USA ed il 50% dei pazienti affetti da tale neoplasia sviluppa metastasi entro 5 ...