Cerca
Items 71-80 di 90
New natural statin-like compounds with anticholesterolemic and antiproliferative properties: "in vitro and in vivo studies"
(2015-12-18)
Il rischio di malattia coronaria è aumentato negli individui che mostrano elevata concentrazione di
colesterolo nelle lipoproteine plasmatiche a bassa densità (LDL). E’ stato dimostrato che
l’inibizione del 3-idrossi-3 ...
Role of PPARy in the complex interplay between brest cancer cells and tumor microenvironment
(2019-03-21)
Stromal Derived Factor-1α (SDF-1α) and its cognate receptor CXCR4 play a key role in
mediating breast cancer cell invasion and metastasis. Therefore, drugs able to inhibit
CXCR4 activation may add critical tools to reduce ...
Benefits of advanced techniques and data processing for the analysis of complex biological and food matrices
(2019-03-03)
Durante i tre anni di dottorato in Medicina Traslazionale, il mio lavoro di ricerca si è concentrato sull'applicazione di tecniche analitiche avanzate e sull'elaborazione dei dati per lo studio di matrici complesse biologiche ...
<<The>> role of intrinsic and extrinsic signals in the regulation of brest cancer stem cell activity
(2015-12-18)
Il carcinoma mammario rappresenta la neoplasia a maggiore incidenza nel sesso femminile. Nonostante i numerosi progressi da un punto di vista diagnostico e terapeutico, metastasi e recidiva tumorale rappresentano ancora ...
Estrogen receptor alpha interferes with LKBl/AMPK/mTOR signaling activation in adiponectin-treated breast cancer cells
(2018-02-27)
Breast cancer is the most common type of tumor and the leading cause of
cancer-related deaths in women, worldwide. The cause of breast cancer is
multifactorial and includes hormonal, genetic and environmental cues. Obesity ...
GPER mediates the up-regulation of acid synthase (fasn) intuced by 17B-estradiol in cancer cell and in cancer-associated fibroblasts (CAFs)
(2012-11-26)
Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of
many tumors. Fatty acid synthase (FASN) is a key lipogenic enzyme catalyzing the terminal
steps in the de novo biogenesis of ...
Polymer-based drug delivery systems: a study on micro and nanoparticles as carriers for bioactive molecules
(2019-04-18)
The works presented in this book are the result of the research carried out by the candidate, Luca Scrivano, during his 3 years Ph.D. at the Department of Pharmacy, Health and Nutritional Sciences of the University of ...
FoxO3a reactivation restores the sensitivity to the antiestrogen treatment in tamoxifen resistant breast cancer
(2017-06-12)
Resistance to endocrine treatments is a major clinical challenge in the management of estrogen
receptor alpha positive (ER+) breast cancers (BC). Although multiple mechanisms leading to
endocrine resistance have been ...
Study of antimicrobial and anticancer activity of new synthetic and natural tools
(2017-06-12)
Infectious diseases and cancer are the two disease groups that representing the major
cause of death worldwide. Unfortunately, antibiotic resistance is the biggest threat in the first
case; in fact, new resistance ...