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<<The>> role of intrinsic and extrinsic signals in the regulation of brest cancer stem cell activity
(2015-12-18)
Il carcinoma mammario rappresenta la neoplasia a maggiore incidenza nel sesso femminile. Nonostante i numerosi progressi da un punto di vista diagnostico e terapeutico, metastasi e recidiva tumorale rappresentano ancora ...
Estrogen receptor alpha interferes with LKBl/AMPK/mTOR signaling activation in adiponectin-treated breast cancer cells
(2018-02-27)
Breast cancer is the most common type of tumor and the leading cause of
cancer-related deaths in women, worldwide. The cause of breast cancer is
multifactorial and includes hormonal, genetic and environmental cues. Obesity ...
GPER mediates the up-regulation of acid synthase (fasn) intuced by 17B-estradiol in cancer cell and in cancer-associated fibroblasts (CAFs)
(2012-11-26)
Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of
many tumors. Fatty acid synthase (FASN) is a key lipogenic enzyme catalyzing the terminal
steps in the de novo biogenesis of ...
Polymer-based drug delivery systems: a study on micro and nanoparticles as carriers for bioactive molecules
(2019-04-18)
The works presented in this book are the result of the research carried out by the candidate, Luca Scrivano, during his 3 years Ph.D. at the Department of Pharmacy, Health and Nutritional Sciences of the University of ...
FoxO3a reactivation restores the sensitivity to the antiestrogen treatment in tamoxifen resistant breast cancer
(2017-06-12)
Resistance to endocrine treatments is a major clinical challenge in the management of estrogen
receptor alpha positive (ER+) breast cancers (BC). Although multiple mechanisms leading to
endocrine resistance have been ...
Study of antimicrobial and anticancer activity of new synthetic and natural tools
(2017-06-12)
Infectious diseases and cancer are the two disease groups that representing the major
cause of death worldwide. Unfortunately, antibiotic resistance is the biggest threat in the first
case; in fact, new resistance ...
Identification and biochemical-molecular characterization of mitochondrial carrier proteins in human andmodel organisms and associated diseases
(2017-06-12)
The mitochondrial carriers (MCs) are transmembrane proteins found in the
mitochondrial inner membrane, which catalyze the translocation of solutes through the
membrane. These belong to a family of carrier proteins, the ...
Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy
(2017-06-12)
Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, ...
Role of ERalpha/NOTCH4 axis in sustaining stemness in breast cancer cells
(2018-02-27)
Early detection and new therapeutic strategies have improved breast cancer patient
outcome and survival rates in the last years. However, breast cancer still remains the
second leading cause of cancer-related deaths among ...