Sfoglia per Soggetto "Recettori"
Items 1-14 di 14
-
Different medicinal chemistry approaches towards the identification of novel targets in breast cancer
(2013-12-02)G protein-coupled receptors (GPCRs) belong to the largest family of cellsurface molecules representing the targets of approximately 40% of current medicinal drugs (Overington, J.P et al 2006). GPCRs are ubiquitous in ... -
Estrogen Receptor beta, through Sp1, recruits a corepressor complex to the Estrogen Receptor alpha gene promoter in breast cancer cells
(2012)Human Estrogen receptors alpha (α) and beta (β) are essential components of a complex signal transduction pathway that regulates mammary growth and development. Several studies have reported that normal breast tissues ... -
Il Recettore Estrogenico alfa e IRS-1 (Insulin Receptor Substate-1) come target dell’azione del Recettore Estrogenico beta
(2013-10-21)Estrogen signalling through ERα plays a central role in many diseases such as breast and endometrial cancer, osteoporosis and cardiovascular disease. In 1996 it has been discovered a second estrogen receptor in rat ... -
<<Il>> ruolo del GPER nelle arterie uterine e mesenteriche in gravidanza
(2015-12-16)Low uteroplacental blood flow has been implicated as a cause of pregnancy hypertension and intrauterine fetal growth retardation. A successful pregnancy outcome requires a sufficient uteroplacental blood flow, which increases ... -
Ruolo del sistema endocannabinoide nei meccanismi di neuroprotezione da 17β-estradiolo in un modello sperimentale di ischemia cerebrale focale
(2013-10-28)In questo studio sono stati determinati i livelli endogeni dell’endocannabinoide finora meglio caratterizzato, anandamide (AEA) e l’attività degli enzimi responsabili, rispettivamente, della sua sintesi e degradazione, ... -
<<The>> estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness
(2013-12-02)The role of the Forkhead box class O (FoxO)3a transcription factor in breast cancer migration and invasion is controversial. Here we show that FoxO3a overexpression decreases motility, invasiveness, and anchorage-indep ...