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A computational mechanistic study of potentially evolving platinum based anticancer drugs
(Università della Calabria, 2021)
Metals are known to play a fundamental physiological role inside human
body affecting many of the biological functions. Analogously, metal based
drugs can also have a similar impact. Cisplatin, a simple platinum complex,
is ...
Charatterization of store-operated calcium entry in the neuroimmune response evoked by ischemic preconditioning in mice subjected to middle cerebral artery occlusion
(Università della Calabria, 2021-06-10)
Cerebral ischemia is one of the leading causes of death and long-term disability
worldwide. Currently approved therapies for ischemic stroke are limited to
reperfusion through mechanical recanalization and/or pharmacological ...
Stromal cells in breast cancer microenvironment: molecular mechanisms involved in tumor progression and potential therapeutic targets
(Università della Calabria, 2021-03-26)
Stromal cells in the tumor microenvironment (TME) play an important role in breast cancer progression, metastasis and therapeutic outcome. Among stromal cells, Tumor-Associated Macrophages (TAMs) and Mesenchymal Stem Cells ...