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Role of PPARy in the complex interplay between brest cancer cells and tumor microenvironment
(2019-03-21)
Stromal Derived Factor-1α (SDF-1α) and its cognate receptor CXCR4 play a key role in
mediating breast cancer cell invasion and metastasis. Therefore, drugs able to inhibit
CXCR4 activation may add critical tools to reduce ...
FoxO3a reactivation restores the sensitivity to the antiestrogen treatment in tamoxifen resistant breast cancer
(2017-06-12)
Resistance to endocrine treatments is a major clinical challenge in the management of estrogen
receptor alpha positive (ER+) breast cancers (BC). Although multiple mechanisms leading to
endocrine resistance have been ...