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Estrogen Receptor beta, through Sp1, recruits a corepressor complex to the Estrogen Receptor alpha gene promoter in breast cancer cells
(2012)
Human Estrogen receptors alpha (α) and beta (β) are essential components of a
complex signal transduction pathway that regulates mammary growth and
development. Several studies have reported that normal breast tissues ...
FoxO3a reactivation restores the sensitivity to the antiestrogen treatment in tamoxifen resistant breast cancer
(2017-06-12)
Resistance to endocrine treatments is a major clinical challenge in the management of estrogen
receptor alpha positive (ER+) breast cancers (BC). Although multiple mechanisms leading to
endocrine resistance have been ...