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Study of autophagic and epigenetic mechanisms in experimental models of inflammatory and neuropathic pain for the identification of new pharmacological targets
(2013-11-28)
Pain is defined by IASP as “an unpleasant sensory and emotional experience
associated with actual or potential tissue damage, or described in terms of such
damage” (IASP, 2011). While physiological pain is like a warning ...
<<The>> estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness
(2013-12-02)
The role of the Forkhead box class O (FoxO)3a transcription factor in breast
cancer migration and invasion is controversial. Here we show that FoxO3a
overexpression decreases motility, invasiveness, and anchorage-indep ...
Estrogen Receptor beta, through Sp1, recruits a corepressor complex to the Estrogen Receptor alpha gene promoter in breast cancer cells
(2012)
Human Estrogen receptors alpha (α) and beta (β) are essential components of a
complex signal transduction pathway that regulates mammary growth and
development. Several studies have reported that normal breast tissues ...
Caratterizzazione pre-clinica di una nuova strategia terapeutica per l'ischemia cerebrale identificata mediante drug repurposing di un antibiotico macrolide
(2013-11-30)
Cerebral ischemia is one of the most common causes of disability and mortality worldwide and the only pharmacological treatment currently available is thrombolysis. The understanding of the mechanisms underlying ischemic ...
In vitro mechanism for downregulation of erα expression by epigallocatechim gallate in ER+/PR+ human breast cancer cells
(2013-11-26)
La prolungata esposizione agli estrogeni rappresenta un fattore di rischio per lo
sviluppo e la progressione del carcinoma mammario, pertanto la terapia antiestrogenica
è considerata l’approccio terapeutico di elezione ...
Chenodeoxycholic acid (CDCA) through TGR5-dependent CREB-signaling activation enhances Cyclin D1 expression and promotes human endometrial cancer cell proliferation
(2011)
Increasing epidemiologic data in humans as well as many in vitro investigative
reports suggest that overweight and obesity are important risk factors for type-I
EC which is the most common malignancy in women and accounts ...