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Transition metal-based complexes as chemitherapeutic agents. Theoretical investigation of MoA, interaction with biological molecules and environmental conditions
(2017-05-05)
Molti metalli e, conseguentemente, molti complessi metallici svolgono ruoli importanti all’interno di sistemi biologici e biochimici. Oggigiorno, è risaputo che essi rappresentano ingredienti molto importanti per la vita ...
Computational study of new drugs for photodynamic therapy
(2017-05-05)
Photodynamic'therapy'(PDT)'is'a'non:invasive'therapeutic'technique'
for' the' treatment' of' different' kind' of' tumours' through' the' production' of'
reactive'oxygen'species'(ROS)'that'act'as'cytotoxic'agents.''''
PDT'works' ...
Eco-friendly extraction of bioactive compounds from olive (drupes and leaves), Stevia and Schizochytrium sp.
(2017-04-13)
The use of nutraceutical compounds, as well as their extraction from natural sources, is
now the subject of studies in various sectors.
The research groups working in this field focus their attention on the optimization ...
FoxO3a reactivation restores the sensitivity to the antiestrogen treatment in tamoxifen resistant breast cancer
(2017-06-12)
Resistance to endocrine treatments is a major clinical challenge in the management of estrogen
receptor alpha positive (ER+) breast cancers (BC). Although multiple mechanisms leading to
endocrine resistance have been ...
Study of antimicrobial and anticancer activity of new synthetic and natural tools
(2017-06-12)
Infectious diseases and cancer are the two disease groups that representing the major
cause of death worldwide. Unfortunately, antibiotic resistance is the biggest threat in the first
case; in fact, new resistance ...
Identification and biochemical-molecular characterization of mitochondrial carrier proteins in human andmodel organisms and associated diseases
(2017-06-12)
The mitochondrial carriers (MCs) are transmembrane proteins found in the
mitochondrial inner membrane, which catalyze the translocation of solutes through the
membrane. These belong to a family of carrier proteins, the ...
Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy
(2017-06-12)
Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, ...
Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
(2017-06-12)
Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved
in the pathogenesis and development of various tumors. We have previously demonstrated
that IGF-IR cooperates with the G-protein ...