Tesi di Dottorato: Recent submissions
Items 301-320 di 1635
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Functional cooperation between GPER and AHR toward breast cancer progression
(2019-04-11)The cytochrome P450 1B1 (CYP1B1) is a heme-thiolate monooxygenase involved in both estrogen and environmental contaminants metabolism. For instance, CYP1B1 catalyzes the hydroxylation of 17-β estradiol (E2) leading to ... -
Chronic kidney disease as an age related disease: new study perspectives fron animal models to hospitalized patents
(2019-04-11)Chronic kidney disease (CKD) is a major public health problem worldwide and its main consequences include the loss of renal function leading to end-stage renal disease (ESRD), an increased risk of cardiovascular disease ... -
Eco-friendly additives for sustainable road pavements
(2019-04-18)L'obiettivo del presente studio è quello di sviluppare e valutare l'efficacia di nuovi additivi non tossici ed eco-compatibili per il settore delle pavimentazioni stradali. Attualmente, in tale settore, c'è la tendenza ... -
Polymer-based drug delivery systems: a study on micro and nanoparticles as carriers for bioactive molecules
(2019-04-18)The works presented in this book are the result of the research carried out by the candidate, Luca Scrivano, during his 3 years Ph.D. at the Department of Pharmacy, Health and Nutritional Sciences of the University of ... -
Interface rheology of structured food
(2019-03-18)Proteins are widely used to form and to stabilize the interfacial layers in multiphase systems, due to their surface activity and their ability to give high mechanical resistance to interfacial layers. In the food industry, ... -
Impact of DNA methylation status on plant response to cd explored through a transcriptomic analysis
(2019-04-11)Due to their sessile life style, plants are continuously exposed to a variety of abiotic and biotic stresses which could potentially hinder their growth, development, productivity and survival. In this scenario, it appears ... -
DNA methylation patterns in aging and aging phenotypes
(2019-04-11)During my PhD program, my work has been addressed to the study of the role of epigenetic modifications in aging and in age-related phenotypes. Epigenetics is the study of changes in gene expression that do not involve ... -
PELP1, EGR-1 and ERRα as potential targets for new therapies against adrenocortical carcinoma
(2019-07-30)I Carcinomi surrenalici (ACC) sono tumori rari e altamente aggressivi, associati a una prognosi molto sfavorevole, principalmente a causa di un alto rischio di recidiva e di opzioni terapeutiche limitate (Stojadinovic ... -
Action of the E2/ERβ/PTEN signaling in the metabolic reprogramming of TCam 2, human melanoma cell line
(2019-03-21)I tumori maligni più abbondanti nella popolazione maschile di età compresa tra i 17 ed i 45 anni, sono i tumori delle cellule germinali (GCTs). Essi comprendono un gruppo eterogeneo di neoplasie in termini istologici, ... -
Development and optimization of analytical protocols based on microextraction techniques for clinical screening and environmental control
(2019-03-21)The development of analytical protocols for the determination of analytes at trace levels in complex matrices (e.g. biological fluids or contaminated water) is a crucial point for the environmental assessment and monitoring ... -
Genomics based discovery and anticancer activity assessment of new thioviridamide-like molecules produced by actinobacteria
(2019-03-21)Fin dalla scoperta della penicillina da parte di Alexander Fleming nel 1928, i prodotti naturali microbici hanno rappresentato una risorsa essenziale per lo sviluppo di nuovi agenti farmacologici. All’interno dell’immenso ... -
Benefits of advanced techniques and data processing for the analysis of complex biological and food matrices
(2019-03-03)Durante i tre anni di dottorato in Medicina Traslazionale, il mio lavoro di ricerca si è concentrato sull'applicazione di tecniche analitiche avanzate e sull'elaborazione dei dati per lo studio di matrici complesse biologiche ... -
Role of PPARy in the complex interplay between brest cancer cells and tumor microenvironment
(2019-03-21)Stromal Derived Factor-1α (SDF-1α) and its cognate receptor CXCR4 play a key role in mediating breast cancer cell invasion and metastasis. Therefore, drugs able to inhibit CXCR4 activation may add critical tools to reduce ... -
Enhancing and Applying Answer Set Programming: Lazy Constraints, Partial Compilation and Question Answering
(2019-01-17)This work is focused on Answer Set Programming (ASP), that is an expressive formalism for Knowledge Representation and Reasoning. Over time, ASP has been more and more devoted to solving real-world problems thanks to ... -
Domain specific languages for parallel numerical modeling on structured grids
(2019-01-17)High performance computing (HPC) is undergoing a period of enormous change. Due to the di culties in increasing clock frequency inde nitely (i.e., the breakdown of Dennard's scaling and power wall), the current direction is ...