Regolazione dell'orologio circadiano nei mammiferi mediante SUMOylazione dell'attivatore trascrizionale BMAL1
Creato da
Giordano, Francesca
Tota, Bruno
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Abstract
The molecular machinery that governs circadian rhythmicity is based on
clock proteins organized in regulatory feedback loops. Although
posttranslational modification of clock proteins is likely to finely
control their circadian functions, only limited information is available to
date. Here, we show that BMAL1, an essential transcription factor
component of the clock mechanism, is SUMOylated on a highly
conserved lysine residue (Lys259) in vivo. BMAL1 shows a circadian
pattern of SUMOylation that parallels its activation in the mouse liver.
SUMOylation of BMAL1 requires and is induced by CLOCK, the
heterodimerization partner of BMAL1. Ectopic expression of a SUMOdeficient
BMAL1 demonstrates that SUMOylation plays an important
role in BMAL1 circadian expression and clock rhythmicity. This reveals
an additional level of regulation within the core mechanism of the
circadian clock.; Università della Calabria, Dottorato di Ricerca in Biologia animale, Ciclo XIX, a.a.2005-2006Soggetto
Fisiologia animale; Mammiferi
Relazione
MED/04;