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Regolazione dell'orologio circadiano nei mammiferi mediante SUMOylazione dell'attivatore trascrizionale BMAL1

dc.contributor.authorGiordano, Francesca
dc.contributor.authorTota, Bruno
dc.date.accessioned2013-05-07T12:24:21Z
dc.date.available2013-05-07T12:24:21Z
dc.date.issued2006
dc.identifier.urihttp://hdl.handle.net/10955/238
dc.identifier.urihttps://doi.org/10.13126/unical.it/dottorati/238
dc.description.abstract4 Abstract The molecular machinery that governs circadian rhythmicity is based on clock proteins organized in regulatory feedback loops. Although posttranslational modification of clock proteins is likely to finely control their circadian functions, only limited information is available to date. Here, we show that BMAL1, an essential transcription factor component of the clock mechanism, is SUMOylated on a highly conserved lysine residue (Lys259) in vivo. BMAL1 shows a circadian pattern of SUMOylation that parallels its activation in the mouse liver. SUMOylation of BMAL1 requires and is induced by CLOCK, the heterodimerization partner of BMAL1. Ectopic expression of a SUMOdeficient BMAL1 demonstrates that SUMOylation plays an important role in BMAL1 circadian expression and clock rhythmicity. This reveals an additional level of regulation within the core mechanism of the circadian clock.
dc.description.sponsorshipUniversità della Calabria, Dottorato di Ricerca in Biologia animale, Ciclo XIX, a.a.2005-2006en_US
dc.language.isoiten_US
dc.relation.ispartofseriesMED/04;
dc.subjectFisiologia animaleen_US
dc.subjectMammiferien_US
dc.titleRegolazione dell'orologio circadiano nei mammiferi mediante SUMOylazione dell'attivatore trascrizionale BMAL1en_US
dc.typeThesisen_US


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