Dipartimento di Farmacia e Scienze della Salute e della Nutrizione - Tesi di Dottorato
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Questa collezione raccoglie le Tesi di Dottorato afferenti al Dipartimento di Farmacia e Scienze della Salute e della Nutrizione dell'Università della Calabria.
Immissioni Recenti
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Charatterization of store-operated calcium entry in the neuroimmune response evoked by ischemic preconditioning in mice subjected to middle cerebral artery occlusion
(Università della Calabria, 2021-06-10)Cerebral ischemia is one of the leading causes of death and long-term disability worldwide. Currently approved therapies for ischemic stroke are limited to reperfusion through mechanical recanalization and/or pharmacological ... -
Stromal cells in breast cancer microenvironment: molecular mechanisms involved in tumor progression and potential therapeutic targets
(Università della Calabria, 2021-03-26)Stromal cells in the tumor microenvironment (TME) play an important role in breast cancer progression, metastasis and therapeutic outcome. Among stromal cells, Tumor-Associated Macrophages (TAMs) and Mesenchymal Stem Cells ... -
GPER mediates the up-regulation of acid synthase (fasn) intuced by 17B-estradiol in cancer cell and in cancer-associated fibroblasts (CAFs)
(2012-11-26)Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of many tumors. Fatty acid synthase (FASN) is a key lipogenic enzyme catalyzing the terminal steps in the de novo biogenesis of ... -
FoxO3a reactivation restores the sensitivity to the antiestrogen treatment in tamoxifen resistant breast cancer
(2017-06-12)Resistance to endocrine treatments is a major clinical challenge in the management of estrogen receptor alpha positive (ER+) breast cancers (BC). Although multiple mechanisms leading to endocrine resistance have been ... -
Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy
(2017-06-12)Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, ... -
Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
(2017-06-12)Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved in the pathogenesis and development of various tumors. We have previously demonstrated that IGF-IR cooperates with the G-protein ... -
Idrogel funzionali per la veicolazione di principi attivi
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Identification and biochemical-molecular characterization of mitochondrial carrier proteins in human andmodel organisms and associated diseases
(2017-06-12)The mitochondrial carriers (MCs) are transmembrane proteins found in the mitochondrial inner membrane, which catalyze the translocation of solutes through the membrane. These belong to a family of carrier proteins, the ... -
Study of antimicrobial and anticancer activity of new synthetic and natural tools
(2017-06-12)Infectious diseases and cancer are the two disease groups that representing the major cause of death worldwide. Unfortunately, antibiotic resistance is the biggest threat in the first case; in fact, new resistance ... -
Role of ERalpha/NOTCH4 axis in sustaining stemness in breast cancer cells
(2018-02-27)Early detection and new therapeutic strategies have improved breast cancer patient outcome and survival rates in the last years. However, breast cancer still remains the second leading cause of cancer-related deaths among ... -
Targeting systems vulnerabilities in uveal melanoma by CRISPR Cas/9 focal adhesion kinase (FAK) genome editing and therapeutic inhibition
(2018-02-27)Il Melanoma Uveale rappresenta la neoplasia intraoculare più frequente nell’età adulta. Colpisce circa 2,500 individui ogni anno negli USA ed il 50% dei pazienti affetti da tale neoplasia sviluppa metastasi entro 5 ... -
Estrogen receptor alpha interferes with LKBl/AMPK/mTOR signaling activation in adiponectin-treated breast cancer cells
(2018-02-27)Breast cancer is the most common type of tumor and the leading cause of cancer-related deaths in women, worldwide. The cause of breast cancer is multifactorial and includes hormonal, genetic and environmental cues. Obesity ... -
Advanced materials for pharmaceutical and biomedical purposes
(2018-02-27)L'innovazione nella chimica dei materiali e nella nanotecnologia hanno sinergicamente contribuito all'avanzamento e allo sviluppo dei Drug Delivery Systems (DDS) creando devices in grado di proteggere farmaci e sostanze ... -
Polymer-based drug delivery systems: a study on micro and nanoparticles as carriers for bioactive molecules
(2019-04-18)The works presented in this book are the result of the research carried out by the candidate, Luca Scrivano, during his 3 years Ph.D. at the Department of Pharmacy, Health and Nutritional Sciences of the University of ... -
PELP1, EGR-1 and ERRα as potential targets for new therapies against adrenocortical carcinoma
(2019-07-30)I Carcinomi surrenalici (ACC) sono tumori rari e altamente aggressivi, associati a una prognosi molto sfavorevole, principalmente a causa di un alto rischio di recidiva e di opzioni terapeutiche limitate (Stojadinovic ... -
Action of the E2/ERβ/PTEN signaling in the metabolic reprogramming of TCam 2, human melanoma cell line
(2019-03-21)I tumori maligni più abbondanti nella popolazione maschile di età compresa tra i 17 ed i 45 anni, sono i tumori delle cellule germinali (GCTs). Essi comprendono un gruppo eterogeneo di neoplasie in termini istologici, ... -
Genomics based discovery and anticancer activity assessment of new thioviridamide-like molecules produced by actinobacteria
(2019-03-21)Fin dalla scoperta della penicillina da parte di Alexander Fleming nel 1928, i prodotti naturali microbici hanno rappresentato una risorsa essenziale per lo sviluppo di nuovi agenti farmacologici. All’interno dell’immenso ...
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