Sfoglia Dipartimento di Farmacia e Scienze della Salute e della Nutrizione - Tesi di Dottorato per Titolo
Items 22-41 di 101
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Dynamic effects of retinoic acid and its isomers on cancer and physiology
(2010-11-23)In the search for new cancer chemo-preventive compounds, hundreds of naturally occurring molecules have been evaluated. Among these, antioxidants appear to be very promising. In this contest, over the last decade retinoids, ... -
Effects of adiponectin on the progression of breast cancer: role of Estrogen Receptor alpha
(2014-11-28)Adipose tissue is no longer considered an inert tissue for storing energy but is now recognized as an active endocrine organ secreting adipokines, cytokines and a diverse range of inflammatory markers. Adiponectin is ... -
Effects of erythropoietin and stem cell factor on normal and cancer cells: implication for supportive therapy in oncological patients
(2013-10-23)The ability of erythropoietin (Epo) to promote the production of red cells is currently exploited to treat chemotherapy-induced anemia. However, the expression of Epo receptor (EpoR) in a variety of cancer cells suggests ... -
Effetti dell'olio essenziale di Bergamotto (Citrus bergamia Risso et poiteau) su processo autofagico: identificazione dei meccanismi coinvolti e dei componenti responsabili
(2012)Nel presente studio, condotto in vitro, è stato valutato il coinvolgimento del processo autofagico negli effetti biologici dell’olio essenziale di bergamotto, BEO (Citrus Bergamia, Risso et Poiteau), un fitocomplesso ... -
Effetto dell'acido retinoico sulle cellule del leydig: regolazione dell'apoptosi e della steroidogenesi
(2013-06-14)In addition to playing a foundamental role in very diverse processes such as vision and growth and differentiation, vitamin A (retinol) and its main biologically active derivate, retinoic acid (RA), are clearly involved in ... -
Estrogen receptor alpha interferes with LKBl/AMPK/mTOR signaling activation in adiponectin-treated breast cancer cells
(2018-02-27)Breast cancer is the most common type of tumor and the leading cause of cancer-related deaths in women, worldwide. The cause of breast cancer is multifactorial and includes hormonal, genetic and environmental cues. Obesity ... -
Estrogen Receptor beta, through Sp1, recruits a corepressor complex to the Estrogen Receptor alpha gene promoter in breast cancer cells
(2012)Human Estrogen receptors alpha (α) and beta (β) are essential components of a complex signal transduction pathway that regulates mammary growth and development. Several studies have reported that normal breast tissues ... -
FoxO3a reactivation restores the sensitivity to the antiestrogen treatment in tamoxifen resistant breast cancer
(2017-06-12)Resistance to endocrine treatments is a major clinical challenge in the management of estrogen receptor alpha positive (ER+) breast cancers (BC). Although multiple mechanisms leading to endocrine resistance have been ... -
Genomics based discovery and anticancer activity assessment of new thioviridamide-like molecules produced by actinobacteria
(2019-03-21)Fin dalla scoperta della penicillina da parte di Alexander Fleming nel 1928, i prodotti naturali microbici hanno rappresentato una risorsa essenziale per lo sviluppo di nuovi agenti farmacologici. All’interno dell’immenso ...