Sfoglia Dipartimento di Farmacia e Scienze della Salute e della Nutrizione - Tesi di Dottorato per Titolo
Items 73-92 di 101
-
PELP1, EGR-1 and ERRα as potential targets for new therapies against adrenocortical carcinoma
(2019-07-30)I Carcinomi surrenalici (ACC) sono tumori rari e altamente aggressivi, associati a una prognosi molto sfavorevole, principalmente a causa di un alto rischio di recidiva e di opzioni terapeutiche limitate (Stojadinovic ... -
Polymer-based drug delivery systems: a study on micro and nanoparticles as carriers for bioactive molecules
(2019-04-18)The works presented in this book are the result of the research carried out by the candidate, Luca Scrivano, during his 3 years Ph.D. at the Department of Pharmacy, Health and Nutritional Sciences of the University of ... -
Profilo tossicologico dell’Olio Essenziale di Bergamotto (Citrus Bergamia, Risso) in vitro e caratterizzazione dei meccanismi coinvolti
(2011-11-28)L’utilizzo di prodotti contenenti estratti vegetali, compresi gli oli essenziali, è ampiamente diffuso nell’industria cosmetica, alimentare e farmaceutica; tuttavia, i meccanismi alla base dei loro effetti risultano ... -
Relevance of nuclear IRS-1 in breast cancer
(2013-10-23)Insulin receptor substrate 1 (IRS-1), one of the major molecules transmitting signals from the insulin and insulin-like growth factor 1 receptors, has been implicated in breast cancer. Recently, data obtained in different ... -
Role of ERalpha/NOTCH4 axis in sustaining stemness in breast cancer cells
(2018-02-27)Early detection and new therapeutic strategies have improved breast cancer patient outcome and survival rates in the last years. However, breast cancer still remains the second leading cause of cancer-related deaths among ... -
Role of PPARy in the complex interplay between brest cancer cells and tumor microenvironment
(2019-03-21)Stromal Derived Factor-1α (SDF-1α) and its cognate receptor CXCR4 play a key role in mediating breast cancer cell invasion and metastasis. Therefore, drugs able to inhibit CXCR4 activation may add critical tools to reduce ... -
Ruolo del sistema endocannabinoide nei meccanismi di neuroprotezione da 17β-estradiolo in un modello sperimentale di ischemia cerebrale focale
(2013-10-28)In questo studio sono stati determinati i livelli endogeni dell’endocannabinoide finora meglio caratterizzato, anandamide (AEA) e l’attività degli enzimi responsabili, rispettivamente, della sua sintesi e degradazione, ... -
Ruolo di iASPP nella regolazione del Mismatch repair in melanoma
(2014-05-22)Cutaneous melanoma is an aggressive malignancy accounting for 4% of skin cancers but 80% of all skin-cancer related deaths. Its incidence is rapidly rising and advanced disease is notoriously treatment-resistant. The role ... -
Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
(2017-06-12)Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved in the pathogenesis and development of various tumors. We have previously demonstrated that IGF-IR cooperates with the G-protein ... -
Stromal cells in breast cancer microenvironment: molecular mechanisms involved in tumor progression and potential therapeutic targets
(Università della Calabria, 2021-03-26)Stromal cells in the tumor microenvironment (TME) play an important role in breast cancer progression, metastasis and therapeutic outcome. Among stromal cells, Tumor-Associated Macrophages (TAMs) and Mesenchymal Stem Cells ... -
Study of antimicrobial and anticancer activity of new synthetic and natural tools
(2017-06-12)Infectious diseases and cancer are the two disease groups that representing the major cause of death worldwide. Unfortunately, antibiotic resistance is the biggest threat in the first case; in fact, new resistance ...