Sfoglia Dipartimento di Farmacia e Scienze della Salute e della Nutrizione - Tesi di Dottorato per Titolo
Items 89-101 di 101
-
Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
(2017-06-12)Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved in the pathogenesis and development of various tumors. We have previously demonstrated that IGF-IR cooperates with the G-protein ... -
Stromal cells in breast cancer microenvironment: molecular mechanisms involved in tumor progression and potential therapeutic targets
(Università della Calabria, 2021-03-26)Stromal cells in the tumor microenvironment (TME) play an important role in breast cancer progression, metastasis and therapeutic outcome. Among stromal cells, Tumor-Associated Macrophages (TAMs) and Mesenchymal Stem Cells ... -
Study of antimicrobial and anticancer activity of new synthetic and natural tools
(2017-06-12)Infectious diseases and cancer are the two disease groups that representing the major cause of death worldwide. Unfortunately, antibiotic resistance is the biggest threat in the first case; in fact, new resistance ... -
Study of autophagic and epigenetic mechanisms in experimental models of inflammatory and neuropathic pain for the identification of new pharmacological targets
(2013-11-28)Pain is defined by IASP as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage” (IASP, 2011). While physiological pain is like a warning ... -
Study of the expression of a Small Leucin-Rich Proteoglycan, Asporin, in normal human osteoblasts and regulation by breast cancer cells
(2014-11-17)Asporin (ASPN) is an extracellular matrix protein that belongs to the Small Leucine Rich Repeat proteoglycan (SLRP) family. Asporin is abundantly expressed in the articular cartilage of individuals with osteoarthritis. ... -
Targeting systems vulnerabilities in uveal melanoma by CRISPR Cas/9 focal adhesion kinase (FAK) genome editing and therapeutic inhibition
(2018-02-27)Il Melanoma Uveale rappresenta la neoplasia intraoculare più frequente nell’età adulta. Colpisce circa 2,500 individui ogni anno negli USA ed il 50% dei pazienti affetti da tale neoplasia sviluppa metastasi entro 5 ... -
<<The>> estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness
(2013-12-02)The role of the Forkhead box class O (FoxO)3a transcription factor in breast cancer migration and invasion is controversial. Here we show that FoxO3a overexpression decreases motility, invasiveness, and anchorage-indep ... -
<<The>> role of intrinsic and extrinsic signals in the regulation of brest cancer stem cell activity
(2015-12-18)Il carcinoma mammario rappresenta la neoplasia a maggiore incidenza nel sesso femminile. Nonostante i numerosi progressi da un punto di vista diagnostico e terapeutico, metastasi e recidiva tumorale rappresentano ancora ... -
Transcriptional regulation by inositol polyphosphates
(2014-10-27)