Browsing Dipartimento di Farmacia e Scienze della Salute e della Nutrizione - Tesi di Dottorato by Issue Date
Now showing items 1-20 of 105
-
Mechanisms of RA action in steroidogenic tissues and pro-apoptotic effects of combined treatment of breast tumoral cell lines with 9-cis retinoic acid and rosiglitazione
(2008-11-20)Vitamin A (Retinol) plays a central role in many essential biological processes such as vision, immunity, reproduction, growth, development, control of cellular proliferation and differentiation. The main active forms ... -
Il trasportatore di carnitina OCTN2: espressione ed implicazioni fisiopatologiche
(2010)In the present work we studied the plasma membrane transporter of carnitine OCTN2. We firstly investigated the interaction of this transporter with a commonly used drug, the omeprazolo. The carnitine transporter was ... -
Dynamic effects of retinoic acid and its isomers on cancer and physiology
(2010-11-23)In the search for new cancer chemo-preventive compounds, hundreds of naturally occurring molecules have been evaluated. Among these, antioxidants appear to be very promising. In this contest, over the last decade retinoids, ... -
Caratterizzazione del ruolo dell'autofagia in un modello sperimentale di glaucoma acuto
(2011)Il termine glaucoma indica un gruppo eterogeneo di neuropatie ottiche progressive caratterizzate da alterazioni del campo visivo dovute alla morte delle cellule ganglionari retiniche (Retinal Ganglion Cells, RGCs) e alla ... -
Cratterizzazione degli effetti neuroprotettivi della leptina in un modello sperimentale di ischemia cerebrale focale nel ratto
(2011)La leptina, oltre ad avere effetti sull’ipotalamo per il controllo del peso corporeo, è coinvolta nella regolazione della funzionalità, dello sviluppo e della sopravvivenza neuronale. Studi recenti hanno evidenziato i ... -
Chenodeoxycholic acid (CDCA) through TGR5-dependent CREB-signaling activation enhances Cyclin D1 expression and promotes human endometrial cancer cell proliferation
(2011)Increasing epidemiologic data in humans as well as many in vitro investigative reports suggest that overweight and obesity are important risk factors for type-I EC which is the most common malignancy in women and accounts ... -
Nuove strategie sperimentali per la comprensione e il trattamento dell’ischemia cerebrale
(2011-11-28)Ischemic stroke is a leading cause of death and long-term disabilities worldwide. Although the pathophysiology of stroke has been studied extensively and several drugs have been proposed in preclinical trials, the ... -
Profilo tossicologico dell’Olio Essenziale di Bergamotto (Citrus Bergamia, Risso) in vitro e caratterizzazione dei meccanismi coinvolti
(2011-11-28)L’utilizzo di prodotti contenenti estratti vegetali, compresi gli oli essenziali, è ampiamente diffuso nell’industria cosmetica, alimentare e farmaceutica; tuttavia, i meccanismi alla base dei loro effetti risultano ... -
Estrogen Receptor beta, through Sp1, recruits a corepressor complex to the Estrogen Receptor alpha gene promoter in breast cancer cells
(2012)Human Estrogen receptors alpha (α) and beta (β) are essential components of a complex signal transduction pathway that regulates mammary growth and development. Several studies have reported that normal breast tissues ... -
Bisphenol A induces gene expression changes an proliferative effects through GPER in breast cancer celles and cancer-associated fibroblasts
(2012)Bisphenol A (BPA) is the principal constituent of baby bottles, reusable water bottles, metal cans, and plastic food containers. BPA exerts estrogen-like activity by interacting with the classical estrogen receptors (ER ...