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Estrogen receptor alpha interferes with LKBl/AMPK/mTOR signaling activation in adiponectin-treated breast cancer cells
(2018-02-27)
Breast cancer is the most common type of tumor and the leading cause of
cancer-related deaths in women, worldwide. The cause of breast cancer is
multifactorial and includes hormonal, genetic and environmental cues. Obesity ...
Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy
(2017-06-12)
Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, ...
Role of ERalpha/NOTCH4 axis in sustaining stemness in breast cancer cells
(2018-02-27)
Early detection and new therapeutic strategies have improved breast cancer patient
outcome and survival rates in the last years. However, breast cancer still remains the
second leading cause of cancer-related deaths among ...