Cerca
Items 1-7 di 7
FoxO3a reactivation restores the sensitivity to the antiestrogen treatment in tamoxifen resistant breast cancer
(2017-06-12)
Resistance to endocrine treatments is a major clinical challenge in the management of estrogen
receptor alpha positive (ER+) breast cancers (BC). Although multiple mechanisms leading to
endocrine resistance have been ...
Study of antimicrobial and anticancer activity of new synthetic and natural tools
(2017-06-12)
Infectious diseases and cancer are the two disease groups that representing the major
cause of death worldwide. Unfortunately, antibiotic resistance is the biggest threat in the first
case; in fact, new resistance ...
Identification and biochemical-molecular characterization of mitochondrial carrier proteins in human andmodel organisms and associated diseases
(2017-06-12)
The mitochondrial carriers (MCs) are transmembrane proteins found in the
mitochondrial inner membrane, which catalyze the translocation of solutes through the
membrane. These belong to a family of carrier proteins, the ...
Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy
(2017-06-12)
Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, ...
Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
(2017-06-12)
Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved
in the pathogenesis and development of various tumors. We have previously demonstrated
that IGF-IR cooperates with the G-protein ...