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Dynamic effects of retinoic acid and its isomers on cancer and physiology
(2010-11-23)
In the search for new cancer chemo-preventive compounds, hundreds of naturally
occurring molecules have been evaluated. Among these, antioxidants appear to be
very promising. In this contest, over the last decade retinoids, ...
Role of PPARy in the complex interplay between brest cancer cells and tumor microenvironment
(2019-03-21)
Stromal Derived Factor-1α (SDF-1α) and its cognate receptor CXCR4 play a key role in
mediating breast cancer cell invasion and metastasis. Therefore, drugs able to inhibit
CXCR4 activation may add critical tools to reduce ...
Stromal cells in breast cancer microenvironment: molecular mechanisms involved in tumor progression and potential therapeutic targets
(Università della Calabria, 2021-03-26)
Stromal cells in the tumor microenvironment (TME) play an important role in breast cancer progression, metastasis and therapeutic outcome. Among stromal cells, Tumor-Associated Macrophages (TAMs) and Mesenchymal Stem Cells ...
Mechanisms of RA action in steroidogenic tissues and pro-apoptotic effects of combined treatment of breast tumoral cell lines with 9-cis retinoic acid and rosiglitazione
(2008-11-20)
Vitamin A (Retinol) plays a central role in many essential biological processes such as
vision, immunity, reproduction, growth, development, control of cellular proliferation and
differentiation. The main active forms ...