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<<The>> role of intrinsic and extrinsic signals in the regulation of brest cancer stem cell activity
(2015-12-18)
Il carcinoma mammario rappresenta la neoplasia a maggiore incidenza nel sesso femminile. Nonostante i numerosi progressi da un punto di vista diagnostico e terapeutico, metastasi e recidiva tumorale rappresentano ancora ...
Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy
(2017-06-12)
Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, ...
Small molecules from cycloaddition reactions: synthesis, theoretical perspectives, and biological evaluation
(Università della Calabria, 2023-02-07)
The research work is related to a Ph.D. course in Translational Medicine of the Department of Pharmacy, Health, and Nutritional Sciences, University of Calabria. The project was carried out at the Department of Chemistry ...
Diagnostic challenges for genetic approaches in Amyotrophic Lateral Sclerosis
(Università della Calabria, 2023-02-28)
Over the past years, our understanding of the genetic mechanisms involved in complex diseases, such as Amyotrophic Lateral Sclerosis, has increased dramatically. ALS is a fatal and devastating motor neuron disease for which ...
Breast tumor microenvironment and endocrine resistance: dissecting the molecular link
(Università della Calabria, 2023-07-04)
