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Novel molecular mechanisms involved in the stimulatory action of zinc in breast cancer
(2016-11-22)
Lo Zinco (Zn), minerale essenziale che regola diverse funzioni biologiche, è coinvolto nella
progressione del tumore mammario. In particolare, è stato dimostrato che in seguito all’attivazione
indotta dallo Zn di recettori ...
Bisphenol A induces gene expression changes an proliferative effects through GPER in breast cancer celles and cancer-associated fibroblasts
(2012)
Bisphenol A (BPA) is the principal constituent of baby bottles, reusable water bottles,
metal cans, and plastic food containers. BPA exerts estrogen-like activity by interacting
with the classical estrogen receptors (ER ...
GPER mediates the up-regulation of acid synthase (fasn) intuced by 17B-estradiol in cancer cell and in cancer-associated fibroblasts (CAFs)
(2012-11-26)
Activation of lipid metabolism is an early event in carcinogenesis and a central hallmark of
many tumors. Fatty acid synthase (FASN) is a key lipogenic enzyme catalyzing the terminal
steps in the de novo biogenesis of ...
Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
(2017-06-12)
Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved
in the pathogenesis and development of various tumors. We have previously demonstrated
that IGF-IR cooperates with the G-protein ...
Targeting systems vulnerabilities in uveal melanoma by CRISPR Cas/9 focal adhesion kinase (FAK) genome editing and therapeutic inhibition
(2018-02-27)
Il Melanoma Uveale rappresenta la neoplasia intraoculare più frequente nell’età adulta. Colpisce circa 2,500
individui ogni anno negli USA ed il 50% dei pazienti affetti da tale neoplasia sviluppa metastasi entro 5 ...