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Charatterization of store-operated calcium entry in the neuroimmune response evoked by ischemic preconditioning in mice subjected to middle cerebral artery occlusion
(Università della Calabria, 2021-06-10)
Cerebral ischemia is one of the leading causes of death and long-term disability
worldwide. Currently approved therapies for ischemic stroke are limited to
reperfusion through mechanical recanalization and/or pharmacological ...
Stromal cells in breast cancer microenvironment: molecular mechanisms involved in tumor progression and potential therapeutic targets
(Università della Calabria, 2021-03-26)
Stromal cells in the tumor microenvironment (TME) play an important role in breast cancer progression, metastasis and therapeutic outcome. Among stromal cells, Tumor-Associated Macrophages (TAMs) and Mesenchymal Stem Cells ...
Progesterone Receptor B disrupts the metabolic reprogramming in breast cancer cell lines producing death by blocking energy producing pathways, and p53 may be linked in this tumour suppressive-action
(Università della Calabria, 2021-11-10)
Il carcinoma mammario (BC) rappresenta la più comune causa di morte per neoplasia nella
donna. Nonostante i progressi fatti nella diagnosi precoce e nella terapia, esso resta una delle
forme tumorali con prognosi infausta. ...
Evidence that ANG II/AGTR1 signaling stimulates aromatase activity, enhances local estrogen production involved in Glioblastoma cell growth and progression
(Università della Calabria, 2021-04-01)
Sistemi polimerici multicomponente per la veicolazione di principi attivi
(Università della Calabria, 2021-02-25)
L’attività di ricerca riportata nel presente lavoro di tesi di dottorato si inserisce nel contesto della sintesi e caratterizzazione di materiali multifunzionali per la veicolazione e il direzionamento di principi ...
Advanced functionalized materials for multipurpose applications
(Università della Calabria, 2021-03-21)
Chemical modifications of polyphenols for the development of new molecules foods for the treatment of metabolic disorders
(Università della Calabria, 2020-07-01)
Metabolic disorders represent the principal cause of death in the industrialized world, affecting several people, because of their incorrect lifestyle. Among them, Type 2 Diabetes Mellitus and related comorbidities, such ...
Novel insight into the protective role of androgen receptor in ER-positive breast cancer
(Università della Calabria, 2020-04-17)
Introduction: Androgen receptor (AR) role in breast cancer appears to be clinically relevant and disease context specific. In estrogen receptor (ER) α-positive primary breast cancers, AR positivity correlates with low tumor ...
Synthetic strategies towards short-chain peptides for potential biomedical applications and tumor-targeted mesoporous silica-based drug delivery systems development
(Università della Calabria, 2020-04-17)
My PhD research project was focused on the design and development of short-chain peptides with biomedical applications and on the identification of new peptide synthesis strategies. Briefly, the specific objectives of my ...