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New strategies for the synthesis of functionalized substituted bisphosphonates: chemistry and biological activity
(2012-11-29)
The ever expanding cutting edge technologies in medicine for the benefit of
society, the orthopedic branch is one among those significant branches in
medicine pertaining to bone. Bisphosphonates (BPS) are being ...
Advanced mass spectrometry-based strategies for the isolation and characterization of G protein-coupled estrogen receptor 1(GPR)
(2014-11-28)
Estrogen signaling plays a vital role in breast, ovarian and endometrial cancers.
The actions of estrogen are mainly mediated by classical estrogen receptors, ERα and
ERβ that belongs to the nuclear receptor superfamily. ...
Different medicinal chemistry approaches towards the identification of novel targets in breast cancer
(2013-12-02)
G protein-coupled receptors (GPCRs) belong to the largest family of cellsurface
molecules representing the targets of approximately 40% of
current medicinal drugs (Overington, J.P et al 2006). GPCRs are
ubiquitous in ...