Cerca
Items 91-100 di 101
Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
(2017-06-12)
Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved
in the pathogenesis and development of various tumors. We have previously demonstrated
that IGF-IR cooperates with the G-protein ...
Targeting systems vulnerabilities in uveal melanoma by CRISPR Cas/9 focal adhesion kinase (FAK) genome editing and therapeutic inhibition
(2018-02-27)
Il Melanoma Uveale rappresenta la neoplasia intraoculare più frequente nell’età adulta. Colpisce circa 2,500
individui ogni anno negli USA ed il 50% dei pazienti affetti da tale neoplasia sviluppa metastasi entro 5 ...
Characterization of the role of ageing on mechanical and thermal nociception and nocifensive response to formalin test in C57BL/6 Mice
(2014-10-27)
Il dolore cronico, che riduce notevolmente la qualità della vita, interessa un
vasto segmento della popolazione globale (il 25% della popolazione Europea
e più di 100 milioni di cittadini Americani), diventando anche più ...
Charatterization of store-operated calcium entry in the neuroimmune response evoked by ischemic preconditioning in mice subjected to middle cerebral artery occlusion
(Università della Calabria, 2021-06-10)
Cerebral ischemia is one of the leading causes of death and long-term disability
worldwide. Currently approved therapies for ischemic stroke are limited to
reperfusion through mechanical recanalization and/or pharmacological ...
Stromal cells in breast cancer microenvironment: molecular mechanisms involved in tumor progression and potential therapeutic targets
(Università della Calabria, 2021-03-26)
Stromal cells in the tumor microenvironment (TME) play an important role in breast cancer progression, metastasis and therapeutic outcome. Among stromal cells, Tumor-Associated Macrophages (TAMs) and Mesenchymal Stem Cells ...