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Items 41-50 di 101
Modelli sperimentali cellulari e molecolari per la valutazione della tossicità di xenobiotici
(2013-12-02)
The aim of my thesis was to find two different experimental models to study cellular and
molecular xenobiotics toxicity. In the first part of the present work we studied the interaction
between two different plasma ...
Nuove strategie sperimentali per la comprensione e il trattamento dell’ischemia cerebrale
(2011-11-28)
Ischemic stroke is a leading cause of death and long-term disabilities worldwide.
Although the pathophysiology of stroke has been studied extensively and several drugs have been proposed in preclinical trials, the ...
Study of autophagic and epigenetic mechanisms in experimental models of inflammatory and neuropathic pain for the identification of new pharmacological targets
(2013-11-28)
Pain is defined by IASP as “an unpleasant sensory and emotional experience
associated with actual or potential tissue damage, or described in terms of such
damage” (IASP, 2011). While physiological pain is like a warning ...
<<The>> estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness
(2013-12-02)
The role of the Forkhead box class O (FoxO)3a transcription factor in breast
cancer migration and invasion is controversial. Here we show that FoxO3a
overexpression decreases motility, invasiveness, and anchorage-indep ...
Estrogen Receptor beta, through Sp1, recruits a corepressor complex to the Estrogen Receptor alpha gene promoter in breast cancer cells
(2012)
Human Estrogen receptors alpha (α) and beta (β) are essential components of a
complex signal transduction pathway that regulates mammary growth and
development. Several studies have reported that normal breast tissues ...
Profilo tossicologico dell’Olio Essenziale di Bergamotto (Citrus Bergamia, Risso) in vitro e caratterizzazione dei meccanismi coinvolti
(2011-11-28)
L’utilizzo di prodotti contenenti estratti vegetali, compresi gli oli essenziali, è ampiamente
diffuso nell’industria cosmetica, alimentare e farmaceutica; tuttavia, i meccanismi alla base
dei loro effetti risultano ...
Caratterizzazione pre-clinica di una nuova strategia terapeutica per l'ischemia cerebrale identificata mediante drug repurposing di un antibiotico macrolide
(2013-11-30)
Cerebral ischemia is one of the most common causes of disability and mortality worldwide and the only pharmacological treatment currently available is thrombolysis. The understanding of the mechanisms underlying ischemic ...
In vitro mechanism for downregulation of erα expression by epigallocatechim gallate in ER+/PR+ human breast cancer cells
(2013-11-26)
La prolungata esposizione agli estrogeni rappresenta un fattore di rischio per lo
sviluppo e la progressione del carcinoma mammario, pertanto la terapia antiestrogenica
è considerata l’approccio terapeutico di elezione ...