Cerca
Items 11-20 di 27
Role of PPARy in the complex interplay between brest cancer cells and tumor microenvironment
(2019-03-21)
Stromal Derived Factor-1α (SDF-1α) and its cognate receptor CXCR4 play a key role in
mediating breast cancer cell invasion and metastasis. Therefore, drugs able to inhibit
CXCR4 activation may add critical tools to reduce ...
Benefits of advanced techniques and data processing for the analysis of complex biological and food matrices
(2019-03-03)
Durante i tre anni di dottorato in Medicina Traslazionale, il mio lavoro di ricerca si è concentrato sull'applicazione di tecniche analitiche avanzate e sull'elaborazione dei dati per lo studio di matrici complesse biologiche ...
Estrogen receptor alpha interferes with LKBl/AMPK/mTOR signaling activation in adiponectin-treated breast cancer cells
(2018-02-27)
Breast cancer is the most common type of tumor and the leading cause of
cancer-related deaths in women, worldwide. The cause of breast cancer is
multifactorial and includes hormonal, genetic and environmental cues. Obesity ...
FoxO3a reactivation restores the sensitivity to the antiestrogen treatment in tamoxifen resistant breast cancer
(2017-06-12)
Resistance to endocrine treatments is a major clinical challenge in the management of estrogen
receptor alpha positive (ER+) breast cancers (BC). Although multiple mechanisms leading to
endocrine resistance have been ...
Study of antimicrobial and anticancer activity of new synthetic and natural tools
(2017-06-12)
Infectious diseases and cancer are the two disease groups that representing the major
cause of death worldwide. Unfortunately, antibiotic resistance is the biggest threat in the first
case; in fact, new resistance ...
Identification and biochemical-molecular characterization of mitochondrial carrier proteins in human andmodel organisms and associated diseases
(2017-06-12)
The mitochondrial carriers (MCs) are transmembrane proteins found in the
mitochondrial inner membrane, which catalyze the translocation of solutes through the
membrane. These belong to a family of carrier proteins, the ...
Activated FXR inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy
(2017-06-12)
Cancer-associated fibroblasts (CAFs), the principal components of the tumor stroma, play a central role in cancer development and progression. As an important regulator of the crosstalk between breast cancer cells and CAFs, ...
Role of ERalpha/NOTCH4 axis in sustaining stemness in breast cancer cells
(2018-02-27)
Early detection and new therapeutic strategies have improved breast cancer patient
outcome and survival rates in the last years. However, breast cancer still remains the
second leading cause of cancer-related deaths among ...
Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells
(2017-06-12)
Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved
in the pathogenesis and development of various tumors. We have previously demonstrated
that IGF-IR cooperates with the G-protein ...